This information is gained from the University of North Carolina Healthcare that smokers of cigarettes are at high risk of DNA damage. This is known by the scientists and the masses that smoking cause damage to DNA which leads to lung cancer but now the scientists created a method for successfully mapping the method at a high resolution across the genome.
This innovation in the health sector comes from the laboratory of the Nobel laureate Aziz Sancar, MD, Ph.D., the Sarah Graham Kenan Professor of Biochemistry and Biophysics at the UNC’s school of medicine. In a study which is published in the Proceedings of The National Academy of Sciences, Sancar and his team introduced a unique method for plotting sites on the genome that are suffering repair on a common type of DNA damage. After that, they will use that method or technique to map all the impairment caused by a major chemical carcinogen.
Sancar said. “This is a carcinogen that accounts for about 30 percent deaths in the United States of America, and we now have a genome-wide map of the damage it causes”.
He further said maps like this will help scientists to better understand how smoking-induced cancer originate, how these cancers can resist and why some people are more vulnerable or resistant to cancer.
The team is also hopeful that by giving such information and map which clarifies that how much harmful smoking is at the cellular level might change some smokers thought and habit and they leave smoking. There are 40 million smokers only in the United States of America and billion worldwide.
He further said, “it would be good if it raises awareness of how harmful smoking can be, it also would helpful to drug developers if we knew exactly how DNA damage is repaired throughout the entire genome”.
Sancar won a share of Nobel Prize 2015 for Chemistry for the detailed work he did on the biochemical repair process.
In the study 2015-16 Sancar and partners were using old technique and now they are using two new techniques DNA-adduct damage, one wrought by ultraviolet light and the other is by the common chemo cisplatin. And Sancar said, “This new method can be applied to any type of DNA damage that involves nucleotide excision repair”.